皮肤黑色素瘤的时间复发:对一系列病例的分析
Paula Resende Salomão1, Matheus Resende Costa Pimenta1, Alberto Julius Alves Wainstein1
1All authors are with Faculdade Ciências Médicas de Minas Gerais, Post-graduation Department, Belo Horizonte, Minas Gerais, Brazil.
The Journal of clinical and aesthetic dermatology
|December 21, 2023
概括
黑色素瘤的复发可能发生迟,甚至在10年后. 这项研究分析了巴西患者,发现年龄较大和男性性别与复发相关,突出显示需要扩展监测.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 流行病学 流行病学
背景情况:
- 皮肤黑色素瘤复发需要持续的患者监测.
- 关于巴西人口特有的黑色素瘤复发模式的数据有限.
研究的目的:
- 调查巴西患者皮肤黑色素瘤复发的特征和时间表.
- 要区分早期 (5年内) 和晚期 (5年后) 的复发概况.
主要方法:
- 追溯分析2006年至2014年间在巴西贝洛霍里森特诊断的331名黑色素瘤患者.
- 收集和统计分析的人口,临床,组织病理和疾病演变数据.
- 统计学意义以小于0.05的p值确定,使用R版本4.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.
主要成果:
- 43名患者出现了黑色素瘤复发.
- 复发病例显示平均年龄更高,男性占主导地位,较低比例的薄瘤 (Breslow厚度<0.8mm),并增加了线粒分裂.
- 早期复发 (n=29) 与瘤有关;晚期复发 (n=14) 不太频繁,但即使在10年后也观察到.
结论:
- 皮肤黑色素瘤可能会在5年后复发,这表明可能需要延长医疗监测.
- 建议进行进一步的多中心研究,以更好地定义早期和晚期黑色素瘤复发的巴西患者个人资料.
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