需要试管婴儿如何影响多胎妊娠中的妊娠并发症? 美国人口数据库的研究,包括近10万次多胎妊娠
Samar Mandourah1, Ahmad Badeghiesh2, Haitham Baghlaf3
1Department of Obstetrics and Gynecology, McGill University, 1001 Decarie Boulevard, Montreal H4A 3J1, Quebec, Canada.
European journal of obstetrics & gynecology and reproductive biology: X
|December 21, 2023
概括
在体外受精 (IVF) 多胎妊娠显示,与自发受孕相比,母亲和新生儿并发症的风险增加. 这些风险在各种不良结果中从20%到70%不等.
科学领域:
- 产科和妇科 产科和妇科
- 生殖医学 生殖医学
- 周围生理学 周围生理学
背景情况:
- 多胎妊娠带有固有的风险.
- 很少有研究比较自发和体外受精 (IVF) 构想的多胎妊娠之间的结果.
- 了解这些差异对于优化产妇和新生儿护理至关重要.
研究的目的:
- 为了比较怀孕,分娩和新生儿在多胎妊娠中的结果,自发怀孕与体外受精 (IVF) 相比.
- 在多胎妊娠中确定与试管婴儿相关的特定风险.
主要方法:
- 使用医疗保健成本和利用计划全国性住院患者样本 (HCUP-NIS) 数据库进行回顾性队列研究.
- 包括 90,552 个自发受孕和 3,219 个通过试管婴儿受孕的多胎妊娠 (2008-2014).
- 多变量逻辑回归分析,调整为混变量.
主要成果:
- 试管婴儿多胎妊娠有更高的妊娠引起的高血压,孕前,妊娠糖尿病和胎盘前的风险.
- 在试管婴儿怀孕中,分娩并发症更频繁,包括剖腹产,子膜过早破裂,胸膜炎,产后出血和输血.
- 试管婴儿怀孕中的新生儿结局与妊娠年龄较小的婴儿和先天异常的风险增加有关.
结论:
- 在体外受精 (IVF) 与多胎妊娠中出现一系列不良孕产妇,分娩和新生儿后果的风险显著增加有关.
- 在IVF多胎妊娠中,确定的风险增加了20%至70%.
- 需要进一步的研究来评估不育本身和特定的试管婴儿协议在这些结果中的作用.
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