美国成年人的大消费和结肠直肠癌风险:一项大型前性队列研究
Zongze Jiang1, Huilin Chen2, Ming Li1,3
1Department of Gastrointestinal, Bariatric and Metabolic Surgery, Research Center for Nutrition, Metabolism and Food Safety, West China-PUMC C.C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Frontiers in nutrition
|December 21, 2023
概括
适度的饮食大摄入量与较低的结直肠癌 (CRC) 风险有关,特别是在男性和远端CRC中. 这些发现表明,大具有保护作用,因癌症亚位点而异.
科学领域:
- 营养流行病学 营养流行病学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 对食大和结肠直肠癌 (CRC) 发病率的流行病学研究产生了不一致的结果.
- 澄清这种关联对于关于预防癌症的公共卫生建议至关重要.
- 需要对美国人口进行大规模前性研究,以解决相互矛盾的发现.
研究的目的:
- 为了前性地评估饮食大消费与结直肠癌 (CRC) 发病率之间的关联.
- 根据CRC子站点和人口因素,调查这种关联的潜在变化.
主要方法:
- 分析了前列腺,肺,结肠直肠和卵巢 (PLCO) 癌症查试验中58508名参与者 (年龄在55-74岁之间) 的数据.
- 饮食摄入量使用验证的问卷进行评估;CRC发病率在12.05年的中位数随访期间进行了跟踪.
- 多变量考克斯回归和受限立方线回归用于确定危险比率 (HR),置信区间 (CI) 和剂量反应模式.
主要成果:
- 适度的饮食大消费与整体CRC风险降低显著相关 (HR:0.70,95%CI:0.54-0.91),显示出U形的剂量反应.
- 在男性的整体CRC (HR:0.57,95%CI:0.40-0.81) 和远端CRC (HR:0.62,95%CI:0.42-0.93) 中观察到保护性关联,但不是近端CRC.
- 保护作用在男性,白人和饮酒量较低的人群中更为明显.
结论:
- 适度饮食大消费与美国人口的结直肠癌 (CRC) 风险降低有关.
- 保护性关联因CRC的解剖学亚位点而异,对远端CRC观察到更强的效果.
- 进一步的前性研究是有必要的,以验证这些发现,并探索在不同的人群中特定的亚站点关联.
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