高密度脂蛋白胆固醇水平作为一种独立的保护因素,防止急性胰腺炎的恶化:一项病例对照研究
Qingqiang Ni1,2, Zetao Yu2, Peng Zhang3
1Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
在重症监护室 (ICU) 住院期间,保持高密度脂蛋白胆固醇 (HDL-C) 水平在0.545 mmol/L以上,可以防止急性胰腺炎 (AP) 恶化. 这一发现表明HDL-C是AP严重程度的潜在生物标志物.
科学领域:
- 生物化学 生物化学
- 关键护理医学 关键护理医学
- 胃肠病学 胃肠病学
背景情况:
- 关于高密度脂蛋白胆固醇 (HDL-C) 和急性胰腺炎 (AP) 严重程度之间的联系的证据有限.
- 调查最低的HDL-C水平在重症监护室 (ICU) 停留期间在AP进展中的作用至关重要.
研究的目的:
- 为了检查在ICU停留期间最低的HDL-C水平和AP恶化之间的关系.
- 为了确定预测AP进展的最低HDL-C水平的最佳切割值.
主要方法:
- 从2015年至2021年,对2015年至2021年期间被送往AP的ICU的115名患者进行了回顾性分析.
- 进行了统计分析,包括单变量,多变量和ROC曲线分析.
- 在ICU停留期间最低的HDL-C水平是独立变量;进展到严重的AP (SAP) 是依赖变量.
主要成果:
- 在严重的AP和中度严重的AP组之间观察到最低的HDL-C水平的显著差异 (P <0.05).
- 在同变量调整后,最低的HDL-C水平与SAP发生呈负相关性 (RR=0.897,95% CI:0.827-0.973).
- 在ROC曲线下的面积为0.707,最佳切线为0.545 mmol/L,用于预测AP恶化.
结论:
- 在ICU停留期间,至少0.545mmol/L的HDL-C水平可以作为独立的防护因子,防止AP恶化.
- 这一发现突显了监测HDL-C水平的潜力,可以预测AP的严重程度并指导治疗.
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