在门诊成年人中,COVID-19症状严重程度和轨迹的性别差异
Samuel P Massion1,2, Amanda C Howa1, Yuwei Zhu3
1Department of Health Policy Vanderbilt University Medical Center Nashville Tennessee USA.
Influenza and other respiratory viruses
|December 21, 2023
概括
患有轻度COVID-19的女性报告的总体和全身症状比男性更严重. 这项研究突出了 ambulatory SARS-CoV-2 感染的症状体验中的性别差异.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 性别和性别在健康方面的差异
背景情况:
- 在全球范围内,COVID-19的流行病已经引起了广泛的感染.
- 虽然住院率因性别而异,但非住院患者的轻度COVID-19症状严重程度仍未得到充分研究.
- 了解症状体验的性别差异对于全面的公共卫生管理至关重要.
研究的目的:
- 为了调查和比较在门诊成年男性和女性之间的COVID-19症状的严重程度.
- 在家庭传播研究中分析每日症状严重程度和2周的变化.
- 为了确定在轻度SARS-CoV-2感染的经历中潜在的基于性别的差异.
主要方法:
- 从2020年4月到2021年4月,在田纳西州纳什维尔进行了一项案例确定研究.
- 参与了223名已确认感染SARS-CoV-2的门诊成年人,他们每天通过问卷报告症状.
- 用多变量线性混合效应回归模型来比较男性和女性之间的症状严重程度.
主要成果:
- 与男性 (0.90) 相比,女性 (58%) 报告了较高的平均整体症状严重程度 (1.04).
- 女性的系统和呼吸系统症状明显比男性严重 (p < 0.001).
- 多变量分析证实,女性报告的总体和全身症状严重程度更大,但呼吸系统症状没有.
结论:
- ambulatory SARS-CoV-2 感染的女性报告的整体症状严重程度略高于男性.
- 这些发现表明,在轻度COVID-19疾病期间,性别之间的症状体验有显著差异.
- 进一步的研究可能会探索导致这些观察到的差异的潜在生物学和社会因素.
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