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在SARS-CoV-2的泛动物潜力

Makenzie E Mabry¹, Angela Fanelli², Carla Mavian³

¹Florida Museum of Natural History, University of Florida, Gainesville, Florida, United States.

|December 21, 2023

概括

严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 正在在许多哺乳动物物种中传播,需要在人类人口之外进行更广泛的监测. 术语"泛动物"更好地反映了病毒.

科学领域:

兽医医学兽医医学兽医医学
病毒学病毒学
基因组学就是基因组学.
保护生物学保护生物学

背景情况:

严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 在哺乳动物物种中表现出广泛且不断增加的宿主范围.
了解病毒进化和宿主适应对于控制动物传染病传播至关重要.
以前的研究已经确定了 ангиотензин转化酶2 (ACE2) 受体是病毒易感性的关键因素.

研究的目的:

分析SARS-CoV-2的宿主范围潜力,通过将哺乳动物的基因组与来自哺乳动物分离的遗传数据进行整合.
确定需要加强对SARS-CoV-2的监测的哺乳动物群和家族.
为全球传播SARS-CoV-2提出一个更合适的术语.

主要方法:

哺乳动物物种的遗传学分析.
来自各种哺乳动物宿主的SARS-CoV-2分离物的比较基因组分析.
在敏感物种中评估ACE2受体的保护.

主要成果:

非人类哺乳动物的SARS-CoV-2感染在很大程度上反映了当代人类菌株,一些物种由于广泛的病毒循环而表现出独特的遗传特征.
ACE2受体的保存不是宿主敏感性的唯一决定因素.
特定的哺乳动物类和家族已被确定为增加SARS-CoV-2监测的高优先级候选人.

结论:

由于SARS-CoV-2的广泛和多样化的宿主范围,因此需要将术语从"流行病"转变为"泛动物病",以准确地代表全球动物病性事件.
加强监测策略,包括对已确定的高风险哺乳动物种群进行系统查,对于有效管理至关重要.
政策行动应该具有包容性,应对病毒的更广泛的生态和流行病学范围.

关键词:

这就是SARS-CoV-2病毒.进化进化演化演化演化演化哺乳动物哺乳动物突变是发生在突变中的突变.这是一种泛动物病.

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