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内分泌疗法:从卵巢切除到个性化疗法和信号抑制

Christian Jackisch¹, Athanasios Argyriadis¹

¹Department of Obstetrics and Gynaecology, Sana Klinikum Offenbach, Offenbach, Germany.

Breast care (Basel, Switzerland)

|December 21, 2023

概括

自19世纪末以来,内分泌疗法是治疗激素受体阳性乳腺癌的基石,它继续发展. 新一代药物为早期和晚期阶段提供了新的方法,改善了患者的治疗结果.

科学领域:

在瘤学瘤学.
内分泌学在内分泌学.
药理学药理学是指药理学的学科.

背景情况:

双边卵巢切除术在晚期乳腺癌治疗中表现出早期疗效.
内分泌疗法是激素受体阳性早期 (EBC) 和转移性 (MBC) 乳腺癌的关键治疗方法.

研究的目的:

审查乳腺癌内分泌治疗的历史演变和最近的进展.
突出临床试验中的新型治疗剂和治疗策略.

主要方法:

关于乳腺癌内分泌疗法的文献综述.
讨论从雌激素治疗到新药药物的药物开发.
分析当前的治疗选择和临床试验结果.

主要成果:

从雌激素治疗到抗雌激素和新型向药物的演变.
新的药物类别包括选择性雌激素受体调节剂,降解剂,对抗剂和共对抗剂.
目前的策略是将内分泌疗法与特定患者群体的CDK4/6或PARP抑制剂结合起来.

结论:

内分泌干预仍然是激素敏感乳腺癌在各个阶段的重要治疗方式.
目前正在进行的研究和临床试验正在扩大治疗选择.
个性化治疗策略以临床试验结果和指导方针为指导.

关键词:

乳腺癌乳腺癌乳腺癌乳腺癌的早期发展内分泌疗法是一种内分泌疗法.雌激素受体的受体是什么新的药物新的药物

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