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Updated: Jul 7, 2025

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity
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Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

Published on: December 7, 2019

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在瘤挑战期间,Piezo1促进了最佳的T细胞激活

Muta Abiff1, Mohammad Alshebremi1,2, Melissa Bonner1

  • 1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Oncoimmunology
|December 21, 2023
PubMed
概括

机械敏感通道Piezo1对于T细胞抗瘤免疫是至关重要的. 在T细胞中删除Piezo1会损害免疫反应,导致侵袭性瘤和治疗不响应.

关键词:
癌症免疫学 癌症免疫学这是一个Piezo1.T细胞机械生物学拉布多米索科马 (rhabdomyosarcoma) 是一种肌肉癌.

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