在人类中,急性禁食会降低对渐进性中枢低血压的耐受性
Joshua E Gonzalez1,2, William H Cooke2,3
1Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, Oregon, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|December 21, 2023
概括
急性24小时禁食降低了对中央低血压的耐受性,较低的耐受性与较高的血水平有关. 禁食会损害身体补偿血液体积损失的能力.
科学领域:
- 心血管生理学心血管生理学
- 代谢调节 代谢调节 代谢调节 代谢调节
- 人体生理学 人体生理学
背景情况:
- 急性禁食可能会给健康带来好处,比如降低血压.
- 然而,禁食可能会增加中央低血压期间心血管崩的风险.
- 中心低血压可以由下体负压 (LBNP) 诱导.
研究的目的:
- 为了测试24小时的禁食是否会降低对中央低血压的耐受性,与被养状态相比.
- 为了研究禁食血水平与对低血的耐受性之间的关系.
主要方法:
- 18名参与者进行了24小时的禁食,通过测量血 (β-OHB) 来确认.
- 使用下体负压 (LBNP) 来诱导逐步的中央低血压.
- 测量包括心电图,节拍血压,肌肉交感神经活动 (MSNA),中脑动脉血速 (MCAv) 和前臂血流.
主要成果:
- 禁食增加了血液中的类水平 (0.12 ± 0.04食用 vs. 0.47 ± 0.11 mmol/L禁食).
- 在禁食状态下,对中央低血压的耐受性降低了10% (禁食1370±89秒,禁食1229±94秒).
- 较低的耐受性与空腹血水平负面相关 (R = -0.542,P = 0.02).
- 禁食的参与者在LBNP期间表现出的前臂血管收缩和更大的中风体积减少.
结论:
- 24小时的禁食显著降低了对中央低血压的耐受性.
- 这种降低的耐受性与外周血管收缩受损有关.
- 长时间的禁食可能会损害身体处理血液体积损失的能力.
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