准备,表征和抗癌作用的含有复杂的coixol与β-cyclodextrin聚合物
Xing-Chen Wang1,2,3, Xin-Yu Shen2,3, Lin Chen4
1Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China.
Pharmaceutical biology
|December 21, 2023
概括
这项研究开发了一种水溶性coixol-β-cyclodextrin聚合物 (CDP) 化合物,以增强coixol的作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药用化学 医学化学
- 生物技术是生物技术.
背景情况:
- 科伊克斯 (Coix lacryma-jobi) 含有科伊克索尔,一种具有已证明抗癌性能的化合物.
- 科伊索尔的治疗潜力受到其水溶性较差的限制.
研究的目的:
- 为了制备一种水溶性coixol-β-cyclodextrin聚合物 (CDP) 纳入化合物.
- 评估新型醇-CDP化合物对非小细胞肺癌 (NSCLC) 的抗癌疗效.
主要方法:
- 使用溶剂和冷干燥合成的Coixol-CDP化合物.
- 用高性能液体染色学 (HPLC) 量化的可克索尔含量.
- 通过MTT测定,霍克斯特染色,流细胞计和西斑分析对A549NSCLC细胞进行抗癌效应的评估.
主要成果:
- 成功制备了一种稳定,水溶性醇-CDP化合物,具有高合效率.
- 在A549细胞中,Coixol-CDP与单独的coixol相比显示出显著较低的IC50值.
- 该化合物表现出与亡相关的蛋白质的增强调节.
结论:
- 溶于水的coixol-CDP化合物提供了一种有希望的方法来克服coixol的可溶性限制.
- 这种新的配方显示出在非小细胞肺癌治疗中临床应用的潜力.
- 需要进一步研究coixol-CDP用于NSCLC治疗.
更多相关视频
09:56Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
15.0K
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
11.0K
相关概念视频
Inhibition of Cdk Activity
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Drugs that Destabilize Microtubules
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
