来自贝生树根茎的抗炎烯酸
Tao Xiong1,2, Jia Zeng3, Lu Chen1,2
1School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Journal of agricultural and food chemistry
|December 21, 2023
概括
贝生 (Alpinia zerumbet) 产生了37种特,包括具有抗炎功能的新化合物. 一些化合物抑制了氧化的产生和NF-κB的激活,这表明了治疗应用.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 药用化学 医学化学
背景情况:
- 贝生 (Alpinia zerumbet) 是一种装饰植物,用于传统中医和作为调味剂.
- 阿尔卑斯山的树根 Alpinia zerumbet 是各种类化合物的丰富来源.
研究的目的:
- 从Alpinia zerumbet根茎中分离和识别类植物.
- 评估分离的类的抗炎活性.
主要方法:
- 从Alpinia zerumbet根茎中分离和阐明37种类的结构.
- 使用RAW 264.7用脂多糖 (LPS) 刺激的巨细胞对抗炎症活性的评估.
- 测量氧化的产生和分析NF-κB途径组件 (IL-6,IL-1β,iNOS,COX-2).
主要成果:
- 发现了7种新的特化物 (色氨酸D1-D7) 和5种新的天然存在的特化物 (色氨酸D10-D14).
- 复合物3展示了一个前所未有的四环循环以太系统.
- 化合物4显著抑制了氧化的产生 (IC50 = 5.4 μM).
- 化合物2和3显示出抑制NF-κB核转位的潜力,抑制炎症标志物.
结论:
- 阿尔皮尼亚根茎是具有显著抗炎性质的新型类植物的宝贵来源.
- 贝生中的特定类化合物可能通过调节NF-κB信号通路来产生抗炎作用.
- 这些发现支持的传统使用,并表明它有潜力开发新的抗炎药物.
相关概念视频
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
121
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
121
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
168
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
168
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
141
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
141
01:17Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
207
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
207
01:29Inflammatory Bowel Disease IV: Pharmacological Management
128
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
128