一种混合电挤出聚二松 suture用于肌组织再生
Roxanna E Abhari1, Sarah J B Snelling1, Edyta Augustynak1
1Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
Tissue engineering. Part A
|December 21, 2023
概括
这项研究开发了一种新的混合,将电和挤出纤维结合起来,以改善肌修复. 与现有的临床选择相比,新的线显示出增强的抗拉强度,并促进了更好的纤维细胞附着和增殖.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 整形外科手术 整形外科手术
背景情况:
- 手术修复失败是常见的,原因是愈合能力差, sutures.
- 电材料作为支架提供了前景,但缺乏足够的抗拉强度用于临床使用.
研究的目的:
- 创建和评估一个混合结合电和融挤出纤维的混合.
- 增强机械性能和生物活性,以改善肌修复.
主要方法:
- 混合的制造,采用电罩和融挤出核心.
- 抗拉强度,多孔度和刚度与仅用电和临床 (Vicryl, PDS) 的比较.
- 通过蛋白质吸附和人类腿筋肌纤维细胞的附着和增殖来评估生物活性.
主要成果:
- 混合具的抗拉强度显著增加 (70.1 N),与仅用电的具 (12.9 N) 相比.
- 它表现出比PDS (1693.0 MPa) 和Vicryl (3838.0 MPa) 更低的刚度 (Young的模量:772.6 MPa),但在断裂时具有相似的力.
- 混合显示出比临床更高的纤维细胞附着和扩散,表明增强的生物活性.
结论:
- 成功生产了一种具有提高拉伸强度和降低度的生物活性混合.
- 这种新的设计促进了细胞介导的修复,为目前的肌修复临床选择提供了一个有希望的替代方案.
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