基于血液的阿尔茨海默氏症生物标志物和从中到晚年生活中的认知功能
Xin Wang1, Kelly M Bakulski1,2, Carrie A Karvonen-Gutierrez1
1Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 21, 2023
概括
中年血清阿尔茨海默病 (AD) 生物标志物,如粉样蛋白β (Aβ) 和酸化 (p-tau181),可能预测女性更快的认知衰退. 较低的Aβ42/40比率和较高的p-tau181比率与记忆和处理速度的下降有关.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 妇女健康 妇女健康
背景情况:
- 阿尔茨海默病 (AD) 构成了重大的健康挑战,特别是在老年人群中.
- 早期发现和预测认知衰退对于及时干预至关重要.
- 从中年开始追踪认知变化的纵向研究对于了解疾病轨迹至关重要.
研究的目的:
- 研究中年血清阿尔茨海默病 (AD) 生物标志物与女性纵向认知功能变化之间的关联.
- 为了确定特定的血清生物标志物,包括粉样蛋白β (Aβ) 和蛋白,是否可以预测随着时间的推移认知能力下降.
主要方法:
- 在全国女性健康研究密歇根队列中,分析了来自192名女性的血清样本,基线时的平均年龄为53.3岁.
- 长度随访14年,评估认知功能,使用诸如数字跨度倒测试和符号数字模式测试等测试.
- 线性混合效应模型被用于评估基线血清Aβ42,Aβ42/40比率,化tau181 (p-tau181) 和总tau与认知变化之间的关联,调整混因子.
主要成果:
- 较低的血清粉样蛋白β (Aβ) 42/40比率与数字跨度逆向测试 (DSB) 的更快下降显著相关.
- 较高的血清酸化tau181 (p-tau181) 显示出边界统计学上显著的关联与符号数字模式测试 (SDMT) 的更快速下降.
- 这些发现表明中年血清AD生物标志物对认知轨迹的潜在预测价值.
结论:
- 中年血清阿尔茨海默病 (AD) 生物标志物可能与女性的加速认知衰退有关.
- 作为潜在的认知衰老早期指标,Aβ42/40比率和p-tau181值得进一步研究.
- 需要更大,更多样化的样本研究来验证这些关联并探索临床影响.
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