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Updated: Jul 7, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

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打破骨质细胞-酸恶性循环,通过基于酸响应的有机框架的中和和基因编辑平台来拯救骨质疏松症

Wenzheng Lin1,2,3, Sihan Hu4, Ke Li1,2

  • 1Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225001, P. R. China.

Small (Weinheim an der Bergstrasse, Germany)
|December 21, 2023
PubMed
概括

这项研究开发了新的纳米颗粒来中和酸性骨微环境并抑制RANKL,有效地逆转小鼠骨质疏松症. 这种方法提供了一种新的策略,通过促进骨形成和减少骨再吸收来治疗骨损失.

关键词:
酸中和化 酸中和化基因编辑 基因编辑金属有机框架骨质疏松症是一种骨质疏松症.核因子kappa-B连接体的受体激活剂.

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