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Updated: Jul 7, 2025

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该ncBAF复合体通过BRD9的H3K27ac感应来调节AML中的转录

David C Klein1, Santana M Lardo1, Sarah J Hainer1,2

  • 1Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.

Cancer research communications
|December 21, 2023
PubMed
概括

odomain抑制BRD9 (odomain含蛋白9) 对于急性髓性白血病 (AML) 细胞存活至关重要. 这项研究揭示了BRD9通过控制AML中的染色质可访问性和基因转录来调节骨髓分化.

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