血清中水平与胎盘入侵的关联 之前:来自第三级参考中心的病例对照研究
Nihat Farisoğullari1, Atakan Tanaçan1, Bedri Sakcak1
1Division of Perinatology, Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, Cankaya, Turkey.
概括
在孕妇中,血清中水平显著高于胎盘前和异常侵入性胎盘 (AIP) 的孕妇. 在胎盘前的病例中,Midkine可以作为预测AIP的生物标志物.
科学领域:
- 产科和妇科 产科和妇科
- 生物标志物发现发现
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 胎盘前置是胎盘部分或完全覆盖子宫的情况.
- 异常侵入性胎盘 (AIP) 是与胎盘前相关的严重并发症,具有重大风险.
- 早期预测AIP对于改善母亲的结果至关重要.
研究的目的:
- 为了研究血清中水平和胎盘侵袭在怀孕妇女与胎盘前.
- 评估中作为预测异常侵入性胎盘 (AIP) 的生物标志物的诊断效用.
主要方法:
- 在胎盘前患者和健康对照者之间对血清中水平的比较分析.
- 在有或没有AIP的情况下对胎盘前列病例中评估中水平.
- 接收器操作特征 (ROC) 分析,以确定AIP预测的最佳切断值.
主要成果:
- 与对照组相比,胎盘前期的孕妇的血清中水平显著升高 (1.16 ng/mL与0.18 ng/mL相比,P < 0.001).
- 在有AIP的胎盘前病例中观察到显著更高的血清中水平 (P = 0.004).
- 为预测AIP,确定了血清中的1.19 ng/mL的最佳切割值.
结论:
- 在有胎盘前期和AIP的孕妇中,母体血清中水平升高.
- 血清中基因显示出作为补充生物标志物的潜力,用于预测胎盘前期病例中的AIP,帮助进行放射学和临床评估.
相关概念视频
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...