与运动相关的突然心脏病死亡中的毒理学查:一项跨国观察性研究
Carl J Hansen1, Jesper Svane1, Marie K Palsøe2
1The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark; Department of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark.
JACC. Clinical electrophysiology
|December 21, 2023
概括
与运动相关的突然心脏病死亡 (SrSCD) 主要影响有结构性心脏病的年轻男性. 与非SrSCD相比,SrSCD病例中毒理学查较少,检测到的与SCD相关的药物很少.
科学领域:
- 心脏病学 心脏病学
- 法医毒理学 法医毒理学
- 运动医学 运动医学
背景情况:
- 运动中的突然心脏死亡 (SCD) 是一个关键问题.
- 与运动相关的突然心脏病死亡 (SrSCD) 的毒理学数据有限.
研究的目的:
- 研究和描述在经历SRSCD的年轻人跨国队列中的死后毒理学发现.
- 为了比较SrSCD和非SrSCD病例之间的毒理学概况.
主要方法:
- 分析了来自丹麦,西班牙和澳大利亚的3,189例12-49岁突然心脏病死亡 (SCD) 病例的死后数据.
- 与体育相关SCD (SrSCD) 和非SrSCD组之间的死后发现的比较.
- 对毒理学发现的评估,特别是在SrSCD队列中.
主要成果:
- 与运动相关的SCD (SrSCD) 发生在年轻男性 (36岁,96%男性) 中,并且更频繁地与结构性心脏病 (68%) 相关.
- 在SrSCD中,积极的毒理学查的频率明显低于非SrSCD (43%),相比之下,SrSCD (12%) 的频率明显低,这表明概率降低了82%.
- 非阿片类止痛药是最常见的发现 (3%);与SCD相关的药物仅在SRSCD病例的6%中被检测出来,在有毒性阳性SRSCD中,物质使用障碍 (SUD) 的流行率更高.
结论:
- 与运动相关的突然心脏病死亡主要影响有潜在结构性心脏病的年轻男性.
- 与非SrSCD相比,在SrSCD中观察到的阳性毒理学查的患病率明显较低.
- 在SRSCD病例中,与突然心脏病死亡相关的药物的检测是罕见的.
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