在连续脏替代疗法期间,可能归因于堵塞的代谢障碍
Mattia M Müller1,2, Larina Caspar1, Onur Sazpinar1
1Institute of Intensive Care Medicine, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
Intensive care medicine experimental
|December 21, 2023
概括
连续脏替代疗法 (CRRT) 中的堵塞影响了重症COVID-19患者,与高甘油三和炎症有关. 这影响了过器的透度,需要进一步研究预防策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临界护理医学 临界护理医学
- 生物医学工程 生物医学工程
背景情况:
- 由于未知的分子阻塞,堵塞会逐渐损害脏置换器械的通透性.
- 在CRRT期间,酸盐抗凝剂可以导致代谢性,高血和高血.
- 在COVID-19大流行期间观察到堵塞发生率增加,原因不明.
研究的目的:
- 分析CRRT设备在重症COVID-19患者中堵塞的发生率.
- 评估与堵塞发展相关的时间变化的因素.
- 为了比较不同CRRT设备之间的堵塞率.
主要方法:
- 对接受CRRT的COVID-19患者的回顾性分析 (2020年3月 - 2021年12月).
- 评估了堵塞替代物 (血清,碳酸,) 和CRRT设备类型 (多片,Prismaflex).
- 采用混合效应模型来确定与堵塞相关的因素.
主要成果:
- 中度和严重的堵塞分别发生在15%和19%的患者身上.
- 使用多过器件的27%的CRRT显示出堵塞;Prismaflex没有.
- 堵塞与高甘油,肠道营养和增加白细胞数量相关.
结论:
- 在接受CRRT的重症COVID-19患者中,堵塞是经常出现的问题.
- 过高甘油三血和全身炎症似乎促进了二次膜的形成,影响了过器的通透性.
- 堵塞发生率的设备特异性差异需要进一步调查.
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