干眼的干预措施:系统性审查的概述
Paul McCann1, Zanna Kruoch2, Sarah Lopez3
1Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Aurora.
JAMA ophthalmology
|December 21, 2023
概括
这次审查发现干眼治疗的证据不确,强调需要更好的系统性审查. 对于人工眼和特定疗法等干预措施,需要更多的研究.
科学领域:
- 眼科医生 眼科 眼科
- 基于证据的医学是基于证据的医学.
背景情况:
- 干眼病是一种普遍的疾病,导致患者显著的发病率.
- 系统性审查对于评估患者,临床医生和指南制定者的干眼干预措施至关重要.
- 综述综述综合了多项系统性审查的发现,但对于干眼干燥的干眼干预措施没有任何存在.
研究的目的:
- 总结干眼干预措施可靠系统审查的研究结果.
- 识别干眼治疗当前研究中的证据缺口.
主要方法:
- 搜索了美国科克兰眼睛和视觉卫星数据库,以进行系统审查 (2016-2022).
- 评估系统审查的可靠性,并提取了关键的结果.
- 综合证据使用推,评估,发展和评估 (GRADE) 评级标准来定义确或不确的证据.
主要成果:
- 确定了138个系统审查;26个 (37%) 被认为可靠.
- 没有干眼干预措施显示出确的有效性证据.
- 没有确的证据表明,环境修改,饮食改变,人工眼,点性闭塞,强烈的脉冲光,热脉冲,皮质类固醇,环素A,分泌剂和自身血清对环境修改,饮食改变,人工眼,点性闭塞,强烈的脉冲光,热脉冲,皮质类固醇,环素A,分泌剂和自身血清有潜在的益处.
结论:
- 虽然一些干眼干预措施显示出潜力,但目前还没有确的证据.
- 干眼干预措施的系统审查的质量需要改进.
- 进一步可靠的系统审查是必要的,以评估治疗方法,如lifitegrast,口服抗生素,和湿度室设备.
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