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Updated: Jul 7, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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一个通用协议,用于合成3-甲基醇使用Acenaphthoimidazolyidene-Ligated Oxazoline Palladacycle的合成

Ruoqian Fan1, Haili Wen2, Zhen Chen1

  • 1Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, 159 Longpan Road, Nanjing 210037, China.

Organic letters
|December 21, 2023
PubMed
概括

一种新的催化方法有效地使用易于获得的原料合成N替代的3-甲基英多尔. 这种方法为生物活性化合物提供了广泛的基质范围和高产量.

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Robinson annulation is a base-catalyzed reaction for the synthesis of 2-cyclohexenone derivatives from 1,3-dicarbonyl donors (such as cyclic diketones, β-ketoesters, or β-diketones) and α,β-unsaturated carbonyl acceptors. Named after Sir Robert Robinson, who discovered it, this reaction yields a six-membered ring with three new C–C bonds (two σ bonds and one π bond).
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