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脑瘤限制了再生生长,以确保Drosophila的正确模式

Syeda Nayab Fatima Abidi1, Felicity Ting-Yu Hsu1, Rachel K Smith-Bolton1,2

  • 1Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.

PLoS genetics
|December 21, 2023
PubMed
概括

RNA调节器 脑瘤 (Brat) 通常限制再生生长. 德洛索菲拉的布拉特损失导致增强再生,但通过增加促生长因素,破坏了翅膀模式和毛发形成.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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