乳腺癌中ICOS表达的分子和临床特征通过大规模的转录组数据
Peng Wang1, Qin Zhang1, Hengle Zhang2
1Thyroid and Breast Department III, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.
PloS one
|December 21, 2023
概括
诱导性T细胞刺激器 (ICOS) 表达与侵袭性乳腺癌亚型相关,并影响瘤免疫微环境. 较高的ICOS水平可以预测免疫治疗反应,并改善三阴性乳腺癌的存活率.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 诱导性T细胞共刺激器 (ICOS) 是一个对T细胞功能至关重要的共刺激受体.
- ICOS在乳腺癌发病过程中的特定作用及其治疗含义尚不清楚.
研究的目的:
- 为了研究ICOS在乳腺癌中的表达模式.
- 为了将ICOS表达与临床和分子特征相关联.
- 评估ICOS作为免疫治疗反应和患者生存的潜在生物标志物.
主要方法:
- 在TCGA和METABRIC队列中分析了2994个乳腺瘤样本的转录组数据.
- 在ICOS表达和临床/分子特征之间的相关性分析.
- 基因 Ontology 分析以确定相关的生物途径.
- 评估ICOS与免疫检查点分子和免疫治疗反应的相关性.
主要成果:
- ICOS表达与恶性乳腺癌亚型和较高瘤等级有显著的关联.
- ICOS表达与免疫反应和炎症以及其他免疫检查点分子 (PD1,PDL1,CTLA4,IDO1) 相关联.
- 较高的ICOS表达与三阴性乳腺癌 (TNBC) 的生存率有关,并预测了对抗PDL1免疫疗法的反应.
结论:
- ICOS在调节乳腺瘤免疫微环境方面发挥作用.
- ICOS表达是乳腺癌免疫疗法疗效的潜在预测生物标志物.
- ICOS代表了乳腺癌治疗的有希望的治疗标,特别是在TNBC.
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