小反动物的对比增强计算机断层扫描:山羊和绵羊
Juliette M Caffrey1, Patricia K Thomas1, Susan E Appt2
1Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC, United States of America.
PloS one
|December 21, 2023
概括
这项研究为羊和山羊提供了关键的计算机断层扫描 (CT) 扫描数据,这对于推动生物医学研究和开发这些有价值的动物模型中的计算模型至关重要.
科学领域:
- 生物医学研究的研究.
- 兽医成像检查 兽医成像检查
- 比较解剖学的比较解剖学.
背景情况:
- 由于与人类的生理相似性,小型反动物 (绵羊和山羊) 越来越多地被用于生物医学研究.
- 对于健康的小反动物的基线成像数据存在重大知识差距,这阻碍了研究的可复制性.
- 计算机断层扫描 (CT) 扫描对于开发计算模型和规划干预至关重要.
研究的目的:
- 为了生成和提供全身,对比度增强的CT扫描数据,用于绵羊和山羊标本.
- 为了解决对健康的小反动物缺乏基线成像数据的问题.
- 支持计算建模,设备原型设计和在反动物中进行翻译研究.
主要方法:
- 从一只绵羊和一只山羊 (30-35公斤) 获得全身CT扫描.
- 在多个时间点 (20s,80s,5分钟) 进行了带有和没有静脉对比剂 (1.7mL/kg在2mL/s) 的扫描.
- 使用骨和软组织窗口进行图像重建;获取参数为100kV和400mA.
主要成果:
- 创建了16个不同的全身图像数据集 (2个标本x4个对比度x2个窗口).
- 后对比计时和重建方法显著影响了解剖结构的可视化.
- 完整的数据集可供下载,以促进进一步的研究.
结论:
- 生成的CT扫描数据为小反动物研究提供了必要的基线信息.
- 该资源将有助于开发先进的计算模型和翻译研究.
- 预计这些数据的可用性将减少变异性,并加速在绵羊和山羊模型中的研究.
相关概念视频
Computed Tomography
4.5K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.5K
X-ray Imaging
5.5K
German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
5.5K
Imaging Studies I: CT and MRI
247
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
247
Radiological Investigation I: X-ray and CT
241
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
241
Positron Emission Tomography
4.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.2K
Imaging Studies for Cardiovascular System II:Types of Echocardiography
272
Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
272


