皮质类固醇治疗COVID-19引起的嗅觉功能障碍:随机对照试验的综合系统性审查和元分析
Jian-Ying Wang1, Jiunn-Bey Pao2, Chih-Hsin Lee3,4,5,6
1Department of Pharmacy, New Taipei City Hospital, New Taipei City, Taiwan.
局部皮质类固醇显著改善COVID-19相关的嗅觉功能障碍,增强嗅觉得分. 系统性皮质类固醇没有显示任何益处,需要进一步研究以确定最佳的治疗方案.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 嗅觉功能障碍是COVID-19的一个常见的,影响生活质量的症状.
- 皮质类固醇治疗COVID-19引起的气味丧失的疗效仍在争论中.
- 本系统性审查和元分析评估了针对COVID-19嗅觉功能障碍的皮质类固醇治疗.
研究的目的:
- 评估皮质类固醇治疗在治疗与COVID-19相关的嗅觉功能障碍方面的有效性.
- 分析接受皮质类固醇的患者的嗅觉得分,持续时间和恢复率.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 搜索了PubMed,Cochrane图书馆和Embase数据库,截至2023年3月1日.
- 包括7个RCT和999名参与者,重点关注嗅觉得分,持续时间和恢复.
主要成果:
- 皮质类固醇治疗显示了嗅觉得分的显著改善 (SMD0.55,95% CI:0.15至0.95).
- 局部皮质类固醇是有效的;系统性皮质类固醇不是.
- 更高的剂量和更长的持续时间可能与更好的结果相关,但没有观察到对康复时间或速率的影响.
结论:
- 局部皮质类固醇治疗是治疗COVID-19相关的嗅觉功能障碍的一个有希望的选择.
- 需要进一步的研究,以建立最佳的治疗方案和安全概况.
- 基于当前的证据,不建议在此症候群中使用全身皮质类固醇.
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