金属有机框架作为一种新型的磁热触发按需释放载体
Xueying Ge1,2, Jeotikanta Mohapatra3, Enya Silva4
1Department of Chemistry, University of North Texas, Denton, Texas, 76201, USA.
Small (Weinheim an der Bergstrasse, Germany)
|December 21, 2023
概括
这项研究引入了一种新的磁热触发药物释放 (MTDR) 载体,在金属有机框架内使用氧化铁纳米颗粒. 新设计提高了加热效率,改善了癌症治疗和按需药物输送.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 磁热触发药物释放 (MTDR) 载体提供非侵入性药物输送.
- 目前的MTDR载体由于纳米颗粒聚合和反铁磁相导致加热效率差.
研究的目的:
- 开发一种具有增强加热效率和可控制药物释放的新型MTDR载体.
- 通过一种新的封装方法来克服现有的MTDR系统的局限性.
主要方法:
- 在金属有机框架 (MOF) 中控制各种尺寸的氧化铁纳米颗粒 (IONPs) 的封装.
- 保存MOF形态,多孔性和IONP分离的保护.
- 在封装过程中IONP中氧化反铁磁相,以增强加热.
- 集成一个磁热响应的纳米刷用于按需释放药物.
主要成果:
- 与传统的MTDR系统相比,新型载体显示了更高的加热效率.
- 封装方法成功地将IONP限制在MOF内,防止聚合.
- 载体保持了MOF的结构完整性和多孔性.
- 按需释放药物是在通过交替磁场刺激时实现的.
结论:
- 开发的MTDR载体显示出在瘤部位磁热调节药物剂量的显著潜力.
- 这项技术为联合化疗和磁性高温疗法提供了更高的加热效率.
- 载体还可以作为医学成像中的有效对比剂.
更多相关视频
04:53Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
Published on: May 26, 2023
985
06:53Author Spotlight: Magnetometric Characterization of Intermediates in the Solid-State Electrochemistry of Redox-Active Metal-Organic Frameworks
Published on: June 9, 2023
2.0K
相关概念视频
Properties of Organometallic Compounds
Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.
Eddy Currents
Since eddy currents occur only in conductors, magnets can separate metals from other materials. For example, in a recycling center, trash is dumped in batches down a ramp, beneath which lies a powerful magnet. Conductors in the trash are slowed by eddy currents, while nonmetals in the trash move on, separating from the metals. This works for all metals, not just ferromagnetic ones.
Other major applications of eddy currents appear in metal detectors and the braking systems of trains and roller...
Other major applications of eddy currents appear in metal detectors and the braking systems of trains and roller...
Types Of Superconductors
A superconductor is a substance that offers zero resistance to the electric current when it drops below a critical temperature. Zero resistance is not the only interesting phenomenon as materials reach their transition temperatures. A second effect is the exclusion of magnetic fields. This is known as the Meissner effect. A light, permanent magnet placed over a superconducting sample will levitate in a stable position above the superconductor. High-speed trains that levitate on strong...
Ferromagnetism
Materials like iron, nickel, and cobalt consist of magnetic domains, within which the magnetic dipoles are arranged parallel to each other. The magnetic dipoles are rigidly aligned in the same direction within a domain by quantum mechanical coupling among the atoms. This coupling is so strong that even thermal agitation at room temperature cannot break it. The result is that each domain has a net dipole moment. However, some materials have weaker coupling, and are ferromagnetic at lower...
Potential Due to a Magnetized Object
Magnetic dipoles in magnetic materials are aligned when placed under an external magnetic field. For paramagnets and ferromagnets, dipole alignment occurs in the direction of the magnetic field. However, the dipoles align opposite to the field in the case of diamagnets. This state of magnetic polarization due to the external field is called magnetization. Magnetization is defined as the dipole moment per unit volume. It plays a similar role to polarization in electrostatics.
The vector...
The vector...
Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
