用Cine-MRI序列来确定内部目标体积,用于前列腺MRI导向放射治疗
Ran Wei1, Bin Liang1, Kuo Men1
1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Medical physics
|December 21, 2023
概括
这项研究引入了一种新的内部目标体积 (ITV) 方法,使用电影MRI来准确地管理放射治疗期间的前列腺内断动运动. 新的ITV改善了临床目标体积 (CTV) 覆盖范围,并减少了与传统规划目标体积 (PTV) 相比的目标大小.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学成像医学成像
- 前列腺癌治疗 治疗前列腺癌
背景情况:
- 在前列腺放射治疗中,分离式目标运动会降低治疗的准确性.
- 四维 (4D) 成像可以生成内部目标体积 (ITV),以处理来自膀填充和肠道运动的运动.
- 目前的临床实践缺乏适合的4D成像技术,用于前列腺运动管理.
研究的目的:
- 通过磁共振成像 (MRI) 来确定ITV,用于管理前列腺MRI导向放射治疗中的内分运动.
- 评估拟议的ITV在提高治疗精度方面的有效性.
主要方法:
- 在每个分数之前,使用电影MRI序列生成和调整参考ITV.
- 35名患者的Cine MRI和3D MRI数据被追溯分析.
- 计算了临床目标体积 (CTV) 覆盖率和相对目标体积,并比较了拟议的ITV和传统规划目标体积 (PTVs) 之间的同位素和异位素边际.
主要成果:
- 与同位素 (97.43% ± 0.41%) 和异位素PTV (96.58% ± 0.73%) 相比,拟议的ITV实现了更高的CTV覆盖率 (98.61% ± 0.51%).
- 拟议的ITV具有较小的相对目标大小 (1.79 ± 0.17),而不是异构型 (1.92 ± 0.12) 和同构型PTV (2.21 ± 0.19).
- 观察到CTV覆盖率和相对目标大小的显著差异 (p < 0.05).
结论:
- 与传统的同otropic 和 anisotropic PTV 相比,提议的 ITV 方法提供了优越的 CTV 覆盖范围,目标尺寸较小.
- 这种ITV方法有效地管理了放射治疗期间的前列腺内断裂运动.
- 基于Cine MRI的ITV确定是提高前列腺癌治疗准确性的有希望的策略.
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