在男性的青春期诱导性高纳多类药物与低纳多性高纳多症:系统性审查和元分析
Emma C Alexander1, Duaa Faruqi2, Robert Farquhar2
1Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
European journal of endocrinology
|December 21, 2023
概括
淋巴激素有效地诱导男性的青春期,具有子激素的子激素,促进丸的生长和 virilization. 与人类胆管激素 (hCG) 和卵泡刺激激素 (FSH) 联合治疗显著改善精子生成,而不是单独使用hCG.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 儿科内分泌学 儿科内分泌学
背景情况:
- 催性性腺性催性腺症 (HH) 损害了青春期的发育,原因是缺少 pituitary 催性腺素的分泌.
- 在患有HH的男性中,丸激素治疗有助于病毒化,但不能促进丸生长或精子生成.
- 对HH有效的青春期诱导策略需要进一步研究.
研究的目的:
- 系统地审查和量化治疗实践和雄性腺激素在患有HH的男性青春期结局的疗效.
- 评估不同性腺激素制剂对丸生长,雄性化和精子生成的影响.
- 发现当前研究中的差距,并指导未来的临床实践.
主要方法:
- 一个全面的系统审查和对发表到2022年12月的研究进行元分析.
- 在Medline,Embase,全球健康和PsycINFO数据库中进行了搜索.
- 使用了质量评估工具并注册了PROSPERO (CRD42022381713) 的协议.
主要成果:
- 分析了103项涉及5328名男性HH患者的研究.
- 通常使用的淋巴激素包括hCG,人更年期淋巴激素,FSH和GnRH.
- 在超过98%的分析中,淋巴激素显著增加了丸体积,阴茎大小和丸激素水平.
- 与hCG + FSH的联合治疗比单独使用hCG (40%) 产生更高的精子生成率 (86%).
结论:
- 淋巴激素在诱导HH男性青春期方面表现出显著的有效性.
- 在淋巴激素治疗方案 (选择,剂量,持续时间) 中存在实质性的异质性.
- 进一步的随机对照试验和正式的指导方针是必要的,以优化HH治疗.
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