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在患有PTSD和边界和/或集群C人格障碍的参与者中,在情绪化任务期间的大脑激活

Inga Aarts¹, Chris Vriend², Odile A van den Heuvel²

¹Sinai Centrum, Arkin, Amstelveen, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy and Neurosciences, Boelelaan 1117, Amsterdam, the Netherlands.

NeuroImage. Clinical

|December 21, 2023

概括

研究了创伤后应激障碍 (PTSD) 与边缘性人格障碍 (BPD) 和集群C人格障碍 (CPD) 相关的神经相关性. 研究结果表明,多维人格障碍的概念化,将分离和情绪调节与大脑激活模式联系起来.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
心理学心理学心理学

背景情况:

创伤后应激障碍 (PTSD) 与边缘性人格障碍 (BPD) 和集群C人格障碍 (CPD) 的并发症很常见.
这些并发症的神经支柱在很大程度上是未知的.

研究的目的:

调查PTSD与BPD和/或CPD并发症的神经相关性.
探索大脑激活,分离和情绪调节困难之间的关联.

主要方法:

在患有PTSD+CPD,PTSD+BPD,PTSD+BPD+CPD和对照组的参与者中,功能性MRI (fMRI) 在情绪面部任务期间被使用.
对感兴趣的区域 (ROI) 进行了ANCOVA和贝叶斯分析.
研究了与临床分离和情绪调节措施的关联.

主要成果:

使用ANCOVAs,没有发现大脑激活的显著群体差异.
观察到解离严重程度和右侧胰岛和右后中侧前额叶皮层 (dmPFC) 中的激活之间存在负面关联.
情绪调节问题与减少右dmPFC激活相关.
贝叶斯分析表明,与PTSD+BPD和PTSD+CPD组相比,PTSD+BPD+CPD组在所有ROI中的激活率更高.

结论:

贝叶斯和相关分析支持人格障碍的维度概念化.
这些发现突出了insula和dmPFC在伴随性PTSD和人格障碍的神经生物学中的作用.

关键词:

避免性人格障碍是一种回避性人格障碍.边界性人格障碍是一种边界性人格障碍.集群c个性障碍个性障碍情感面对任务任务任务任务.这是PSTD.功能磁力共振成像 (fMRI) 是一种功能共振成像.

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