设计了血小板细胞电机,以提高癌症辐射敏感性
Wei Liu1, Hongmei Nie1, He Li1
1Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.
Journal of colloid and interface science
|December 21, 2023
概括
装有黄金纳米粒子和尿酶的工程血小板细胞电机积极向瘤. 这些电机通过增加DNA损伤和活性氧物种来增强辐射敏感性,从而提高癌症治疗效率.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 基于细胞的药物输送面临着瘤透和保留方面的挑战.
- 移动微型/纳米发动机显示了增强的交付能力.
- 放射性敏感性可以通过治疗剂的有针对性输送来改善.
研究的目的:
- 设计尿素酶驱动的血小板细胞电机 (PLT@Au@Urease) 用于有针对性的输送放射敏感剂.
- 为了增强瘤向,细胞吸收和放射敏感化.
- 为了在体内评估这些工程发动机的治疗疗效.
主要方法:
- 通过现场合成和将黄金纳米粒子 (放射敏感剂) 装入血小板中来设计血小板细胞电机.
- 与血小板结合尿酶,以创建一个自我推进系统.
- 研究了在含尿素的环境中通过尿酶生物催化反应产生推力.
- 评估了细胞内活性氧物种 (ROS) 水平和核DNA损伤.
- 使用4T1携带的小鼠进行了体内实验.
主要成果:
- PLT@Au@Urease电机表现出活跃的运动和高效的瘤细胞向.
- 与非推进的对照 (PLT@Au) 相比,自行驱动的电机显著增加了细胞内ROS和加剧了DNA损伤.
- 对PLT@Au@Urease实现了1.89的高灵敏度增强率,对PLT@Au@Urease而言是1.08的高灵敏度增强率.
- 在体内研究显示,当PLT@Au@Urease与放射治疗相结合时,具有显著的抗瘤性能.
结论:
- 尿素驱动的血小板细胞电机为增强放射敏感性提供了一个有希望的策略.
- 这种智能细胞运动系统改善了瘤的放射敏感剂的向输送.
- 这些发现扩大了基于细胞运动的药物递送系统在癌症治疗中的应用范围.
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