相关实验视频

Updated: Jul 7, 2025

Fluorimetric Techniques for the Assessment of Sperm Membranes

Fluorimetric Techniques for the Assessment of Sperm Membranes

Published on: November 28, 2018

一项系统性审查,确定精子血生物标志物及其对IVF和ICSI结果的预测能力

Jonna S van den Berg¹, Nerea M Molina², Signe Altmäe³

¹Department of Reproductive Medicine and Gynaecology, Division Female and Baby, University Medical Centre Utrecht, Utrecht, the Netherlands.

Reproductive biomedicine online

|December 21, 2023

概括

精液等离子体 (SP) 含有可以预测辅助生殖技术 (ART) 成功的分子,与目前的精液质量测试不同. 本次审查确定了32种潜在的SP生物标志物用于预测ART结果,提供了一个新的诊断工具.

科学领域:

生殖生物学生殖生物学
生物标志物发现发现
辅助生殖技术辅助生殖技术

背景情况:

精液等离子体 (SP) 是一种复杂的液体,具有发现生物标志物的潜力.
目前的精液质量参数不足以预测辅助生殖技术 (ART) 的结果.
确定可靠的生物标志物对于改善不孕症调查和ART成功率至关重要.

研究的目的:

系统地审查和识别可以预测ART结果的人类SP生物标志物,包括体外受精 (IVF) 和细胞内精子注射 (ICSI).
为在不孕症和辅助生殖中临床应用提供潜在的SP生物标志物的全面概述.

主要方法:

进行了系统的文献搜索,以确定相关的观察队列和病例控制研究.
包括报告SP生物标志物与不孕男性ART结果之间的关联的研究.
潜在的生物标志物被分类为氧化应激标志物,蛋白质,代谢物和核酸等组.

主要成果:

选择了43项研究,分析了89个潜在的SP生物标志物.
在SP中,32个分子被确定为预测ART结果的潜在相关分子.
在多项研究中,介质素-18 (IL-18) 和TGF-β1-IL-18比率被证实是有前途的生物标志物.

结论:

精液血具有重要的,但尚未充分利用的,用于预测ART结果的潜力.
本次审查巩固了32个SP分子作为预测生物标志物的证据,其中IL-18及其比率特别有前途.
需要进一步的研究,以开发使用SP生物标志物的ART非侵入性诊断工具.

关键词:

辅助生殖技术是一种辅助生殖技术.生物标志物生物标志物美国国务院调查局 (ICSI)在这个过程中,IVF IVF.精液等离子体中的精液.

更多相关视频

U-Shaped Horizontal Swimming Technique for Preparing High-Quality Sperm with Low DNA Fragmentation Index

U-Shaped Horizontal Swimming Technique for Preparing High-Quality Sperm with Low DNA Fragmentation Index

Published on: March 28, 2025

Human Egg Maturity Assessment and Its Clinical Application

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

相关概念视频

Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...