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Updated: Jul 7, 2025

Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
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Published on: August 13, 2017

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α-synuclein的Serine-129酸化是生理蛋白-蛋白相互作用和突触功能活动依赖的触发器

Leonardo A Parra-Rivas1, Kayalvizhi Madhivanan2, Brent D Aulston2

  • 1Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.

Neuron
|December 21, 2023
PubMed
概括

在-129 (α-syn Ser129P) 的α-synuclein的酸化是其正常功能的关键,而不仅仅是疾病. 这种修饰调节了突触活动和蛋白质相互作用,为突核蛋白病变提供了新的治疗点.

关键词:
阿尔法折叠是什么意思阿尔法折叠克里斯普尔是什么意思?克里斯普尔是什么意思?氨酸突变 氨酸突变内源性标记是一种内源性标记.神经元活动的神经元活动.在 pH 化物中.近距离连接测定测试.赛林酸化是一种酸化.有关突触的突触.α-synuclein 是一种同核蛋白.

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