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在抗生素治疗期间Mycobacterium的遗传稳定性

Nakwon Kwak¹, Jiyun Park², Sun Ju Kim³

¹Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, The Republic of Korea.

Journal of global antimicrobial resistance

|December 21, 2023

概括

在抗生素治疗期间对Mycobacterium的遗传分析显示,抗生素耐药性基因的变化很小. 持久单个菌株显示稳定的最小抑制度,表明治疗反应的遗传进化有限.

科学领域:

医学微生物学医学微生物学
基因组学就是基因组学.
抗微生物耐药性抗微生物耐药性

背景情况:

菌根 (M. abscessus) 感染的治疗具有挑战性.
了解抗生素治疗期间的遗传适应对于有效的治疗策略至关重要.

研究的目的:

调查从接受抗生素治疗的患者中分离的M.的遗传变化.
为了将这些遗传变化与临床结果和抗菌素敏感性相关联.

主要方法:

在治疗前和治疗后 (12个月) 从两名患者收集的M. abscessus孤立的全基因组测序.
确定服用抗生素的最小抑制度 (MIC).
对与抗微生物耐药性相关的基因中单核酸变异 (SNVs) 的分析.

主要成果:

在这两名患者中都观察到单个M.菌株的持续感染.
没有发现关键抗菌素耐药性基因 (例如,rrl,rrs,erm) 的显著突变.
在治疗期间观察到MIC的最小变化.
不同名的SNVs的积累发生了,但患者之间存在差异,假设蛋白质基因的显著变化.

结论:

在肺部感染中,M. abscessus在12个月的抗生素治疗期间表现出相对的遗传稳定性.
在这些病例中,观察到的遗传变化没有显著影响抗菌素敏感性或临床过程.

关键词:

遗传变化是一种基因变化.没有结核的真菌菌.肺部疾病肺部疾病

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