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相关概念视频

Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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甲基供体微量营养素,下丘脑发育和对代谢疾病的编程.

Ruslan Kubant1, Clara E Cho2, Emanuela Pannia1

  • 1Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada.

Neuroscience and biobehavioral reviews
|December 21, 2023
PubMed
概括

母亲摄入的甲基供体微量营养素,如叶酸和胆,对于胎儿大脑发育至关重要,并可能影响后代.

关键词:
胆 胆 是一种叶酸是什么?叶酸是什么?叶酸是什么?下丘脑的下丘脑是什么意思孕妇的饮食 孕妇的饮食代谢性疾病是一种代谢性疾病.甲基供体微量营养素的提供者神经发育 神经发育

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Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
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科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 营养科学 营养科学

背景情况:

  • 胎内营养显著影响胎儿大脑发育和后代的长期疾病风险.
  • 孕产妇的甲基供体微量营养素在调节神经干细胞功能和下丘脑发育方面发挥着关键作用.

研究的目的:

  • 审查母体甲基供体微量营养素在胎儿神经元发育和下丘脑编程中的作用.
  • 检查对晚年代谢结果和代谢综合征风险的影响.

主要方法:

  • 文献综述侧重于临床前研究和最近的研究.
  • 分析叶酸和胆在单碳代谢和表观遗传修饰中的作用.

主要成果:

  • 甲基捐赠微量营养素 (叶酸,胆) 对于发展大脑中的能量静态通路至关重要.
  • 母体摄入量的不平衡会破坏DNA甲基化模式,影响下丘脑发育.

结论:

  • 由于怀孕期间的叶酸和胆摄入不平衡,DNA甲基化中断会增加后代代谢疾病的风险.
  • 需要进一步的研究,包括人体研究,以确认可翻译性.