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Updated: Jul 7, 2025

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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防止粉样β的寡合化和与柏柏林的聚合:通过计算方法研究作用机制

Faizan Abul Qais1, Nagma Parveen2, Mohd Afzal3

  • 1Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh 202002, India.

International journal of biological macromolecules
|December 21, 2023
PubMed
概括

发现柏柏林可以抑制粉样β聚合,这是阿尔茨海默病等神经系统疾病的关键因素. 这项研究揭示了柏柏林如何打击蛋白质错折,为新药开发提供了潜力.

关键词:
聚合是一种聚合.粉样蛋白β是什么 粉样蛋白β是什么柏柏林蛋白是一种柏柏林蛋白.分子动力学模拟模型寡合化是指一种氧化物.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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