系统性免疫炎症指数与不同糖尿病状态的美国成年人死亡率之间的关系:来自NHANES 1999-2018年的证据
Yujie Tang1, Xiaojin Feng2, Na Liu3
1Affiliated Hospital of Weifang Medical University, Weifang, China; School of Clinical Medicine, Weifang Medical University, Weifang, China.
Experimental gerontology
|December 21, 2023
概括
系统性免疫炎症指数 (SII) 与所有原因和心血管疾病 (CVD) 的死亡风险更高有关. 监测SII至关重要,特别是对于糖尿病患者,因为这些关联在糖尿病状态之间有所不同.
科学领域:
- 流行病学和公共卫生.
- 免疫学和炎症生物标志物
- 心血管疾病研究研究
背景情况:
- 系统性炎症在各种慢性疾病中起作用,包括糖尿病和心血管疾病.
- 系统性免疫炎症指数 (SII) 由血细胞计数得出的,是系统性炎症的潜在标志物.
- 了解SII与不同血糖状况的死亡风险之间的关系对于临床风险分层至关重要.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 与全因死亡率之间的关联.
- 检查SII与心血管疾病 (CVD) 死亡率之间的关联.
- 通过使用NHANES数据,分析美国成年人糖尿病状况分层的这些关联.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) 1999-2018周期的数据.
- 从中性粒细胞,淋巴细胞和血小板数量计算SII;通过国家死亡指数链接分析死亡率数据.
- 采用考克斯回归模型和受限立方线来评估死亡风险和非线性关系.
主要成果:
- 在完全调整的模型中,较高的SII水平与全因死亡率 (HR 1.02) 和心血管疾病死亡率 (HR 1.05) 的增加有关.
- SII与死亡率之间的关联在糖尿病,糖尿病前期和非糖尿病人群中显示出差异.
- 在所有糖尿病状态中观察到SII和全因死亡率之间的非线性"U形"关系;心血管疾病死亡率显示出除糖尿病患者以外的非线性关系.
结论:
- 系统性免疫炎症指数 (SII) 与所有原因和心血管死亡率的风险增加有关.
- 这些关联是由个人的糖尿病状况调节的,突出显示了个性化风险评估的必要性.
- 建议监测SII水平以减轻死亡风险,特别是在不同程度的葡萄糖失调的人群中.
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