与儿童和成人尿路感染相关的遗传多态性:系统性审查和元分析
Jiakun Yu1, Glaucia Miranda Varella Pereira2, Kristina Allen-Brady3
1University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom.
American journal of obstetrics and gynecology
|December 21, 2023
概括
尿路感染具有很强的遗传成分. 本综述综合了基因研究,发现了尿路感染与特定基因变异 (特别是儿童和成人中CXCR1) 之间的关联.
科学领域:
- 遗传学 遗传学是一种遗传学.
- 流行病学 流行病学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 尿路感染 (UTI) 具有很高的遗传性,从儿科到成人复发病例的关联表明有终身易感性因素.
- 之前对尿路感染的遗传关联研究缺乏当代的系统合成.
研究的目的:
- 系统地审查与儿童和成人尿路感染相关的遗传多态性.
- 评估报告的尿路感染遗传关联的强度,一致性和偏差风险.
主要方法:
- 2005年1月1日至2023年11月16日期间发表的研究的系统审查和元分析.
- 在PubMed,HuGE Navigator和Embase中使用遗传和表型关键字进行了搜索.
- 分析使用了共同主导的继承模型,使用威尼斯标准来评估可信度.
主要成果:
- 22项研究 (7项成人,15项儿科) 被纳入了分析.
- 儿童尿路感染与CXCR1,IL8,TGF,TLR4和VDR的变化存在显著的聚合关联.
- 在CXCR1变异的成年尿路感染中发现了显著的聚合关联;在CXCR1中rs2234671在两个人群中都显示出一致性.
结论:
- 本综述综合了儿科和成人群体中尿路感染的遗传结构.
- 虽然聚合协会的整体可信度很弱,但CXCR1变异,特别是rs2234671,表明在尿路感染病原发生过程中发挥了关键作用.
- 这些发现为未来对尿路感染的遗传关联研究提供了有价值的信息.
相关概念视频
01:20Disorders of the Urinary System
319
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
319
01:05Single Nucleotide Polymorphisms-SNPs
15.1K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.1K
02:26Comparing Copy Number Variations and SNPs
17.7K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.7K
01:26Sexually Transmitted Infections
317
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
317
01:26Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
02:46Genome Copying Errors
4.2K
DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their survival. Therefore, the copying errors are checked and repaired at three levels.
4.2K