Bifidobacterium breve M-16V通过肠道环境调节自主神经系统:一项双盲,安慰剂控制的研究
Natsumi Mutoh1, Masamichi Moriya2, Chendong Xu1
1Innovative Research Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, Zama-city, Kanagawa 252-8583, Japan.
Behavioural brain research
|December 21, 2023
概括
Bifidobacterium breve M-16V补充剂改善了焦虑个体的情绪和睡眠. 这种益生菌影响了肠道微生物群的代谢物和自主神经系统活动.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
背景情况:
- 肠道微生物群在肠道-大脑轴中发挥作用.
- 益生菌正在研究它们对心理健康的影响.
- 双细菌简短M-16V是一种特定的细菌株,具有潜在的精神病菌性质.
研究的目的:
- 评估Bifidobacterium breve M-16V在改善人类情绪方面的疗效.
- 探索B. breve M-16V对生理应激反应的影响.
- 评估与情绪相关的肠道微生物群代谢物的变化.
主要方法:
- 随机对照试验 (RCT) 进行6周的干预.
- 使用Bifidobacterium breve M-16V (每天20亿个细胞).
- 使用近红外光谱学 (NIRS) 和便分析评估情绪,睡眠和生理压力.
主要成果:
- B. breve M-16V摄入量在精神压力期间降低了心率.
- 在便样本中观察到增加的pipecolic acid,一种类似GABA的物质.
- 高焦虑的参与者在情绪和睡眠得分上有显著的改善.
结论:
- 比菲多细菌简短M-16V显示出作为一种精神病菌的潜力.
- 益生菌影响肠道微生物群的代谢物和自主神经系统调节.
- B. breve M-16V可能为管理情绪和睡眠障碍提供一种新的方法,特别是在焦虑的人群中.
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