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在老鼠中,Anonna crassiflora通过其抗氧化作用,生物活性胺和含量来抑制结肠癌发生

Patrícia Felix Ávila¹, Angélica Pereira Todescato¹, Mylena de Melo Carolo Dos Santos²

¹Programa de Pós-graduação em Nutrição e Longevidade, Universidade Federal de Alfenas, Alfenas, UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, MG 37130-001, Brazil.

Food research international (Ottawa, Ont.)

|December 21, 2023

概括

马罗罗水果提取物通过减少前新形成性病变,在老鼠中显示出对结肠癌的化学预防作用. 这种保护作用与其丰富的抗氧化物质,化合物,黄类化合物和精氨酸含量有关.

科学领域:

* 营养生物化学和食品科学
* 癌症化疗预防研究
* 药物鉴定和植物化学

背景情况:

*巴西的塞拉多果实,马罗罗 (Annona crassiflora),由于对其生物活性化合物的研究有限,未得到充分利用.
* 化学预防策略对于管理致癌物诱导的前瘤病变至关重要.
* 了解像马罗罗这样的土著水果的功能性质可以提供新的健康益处.

研究的目的:

* 为了研究马罗罗肉质对威斯塔尔大鼠1,2-二甲基 (DMH) 诱导的结肠前瘤病变的化学预防潜力.
* 为了将观察到的化学预防作用与马罗罗纸的抗氧化活性,化合物和生物活性氨基含量相关联.

主要方法:

*使用光谱光度和UPLC-DAD的总化合物 (TPC) 和总类化合物 (TFC) 的量化.
*通过HPLC-FLD.确定自由生物活性氨基 (泰拉胺,普特雷辛,精子胺)
*使用DPPH和ABTS试验进行体外抗氧化活性评估.
*使用DMH在Wistar大鼠中诱导前瘤病变,并在马洛洛肉给药后通过异常密室焦点 (ACF) 试验进行评估.

主要成果:

* 马罗罗纸表现出高TPC (9.16毫克GAE/g) 和TFC (7.26毫克CE/g),其中酸和甲作为主要的基.
*检测到含有大量生物活性氨基,包括提拉胺 (31.97毫克/公斤),普特雷辛 (20.65毫克/公斤) 和精子胺 (6.32毫克/公斤).
* 马罗罗肉在所有测试度 (0.7,1.4和2.8g/kg bw/day) 上显著抑制了DMH诱导的前新生病变.

结论:

* 马罗罗肉对DMH诱导的结肠癌发生有显著的化学预防作用.
* 抗氧化活性,归因于其丰富的和黄含量,可能有助于观察到的保护作用.
* 精氨酸的存在也可能在marolo肉质对结肠癌的化学预防中发挥作用.

关键词:

异常的密室焦点具有抗氧化活性的抗氧化剂.化学预防化学预防马洛洛·马罗洛 (Marolo Marolo) 是一个非常出色的演员.精子胺是什么精子胺是什么

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