来自SNB的后生物成分对肠道屏障功能障碍和肠道微生物群组成的影响
Luyao Xiao1, Changliang Zhang2, Xueliang Zhang1
1Sanya Institute of Nanjing Agricultural University, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.
Food research international (Ottawa, Ont.)
|December 21, 2023
概括
细菌的表面分子,囊多糖 (B-CPS) 和表面层蛋白 (B-SLP),充当后生物. 它们改善了肠道微生物群的组成,增加了短链脂肪酸的产生,支持肠道健康.
科学领域:
- 微生物学 微生物学
- 肠道微生物组研究研究
- 营养科学 营养科学
背景情况:
- 细菌表面成分显示出对肠道健康的潜在影响.
- 这些成分对肠道微生物群调节的机制尚未完全理解.
研究的目的:
- 为了研究从Lacticaseibacillus paracasei S-NB中囊多糖 (B-CPS) 和表面层蛋白 (B-SLP) 的后生物潜力.
- 评估它们对肠上皮质屏障功能和肠道微生物群组成的影响.
主要方法:
- 提取B-CPS和B-SLP从Lacticaseibacillus paracasei S-NB.中提取的方法
- 对LPS诱导的Caco-2细胞模型的保护作用的验证.
- 在体外发酵测试使用便培养来评估后生物潜力和微生物群调节.
主要成果:
- B-CPS和B-SLP证明了对肠上皮质屏障功能障碍的保护作用.
- B-CPS和B-SLP作为Lactobacillus生长的碳和来源.
- 在体外发酵调节了肠道微生物群,增加了有益的细菌 (例如,Bacteroides,Bifidobacterium) 和减少了病原体 (例如,Escherichia-Shigella).
- 观察到总短链脂肪酸生产的显著增加.
结论:
- B-CPS和B-SLP表现出显著的后生物特性.
- 这些成分可以积极调节肠道微生物群的组成和功能.
- 结果支持B-CPS和B-SLP作为后生物质用于增强人类肠道健康的应用.
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