在超重的拉丁裔儿童中,炎症生物标志物和胰岛素抵抗之间的关系
Mariano Nicolás Aleman1, María Constanza Luciardi1, Emilce Romina Albornoz1
1Departamento de Bioquímica Aplicada, Facultad de Bioquímica, Químicay Farmacia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Argentina.
Clinical and experimental pediatrics
|December 21, 2023
概括
胰岛素抵抗 (IR) 在超重和肥胖的拉丁裔儿童中非常普遍. 虽然几种炎症生物标志物显示出差异,但它们不能可靠地预测这个人群中的IR状态.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢健康 代谢健康
- 炎症研究 炎症研究
背景情况:
- 超重,炎症和胰岛素抵抗 (IR) 是相互关联的健康问题.
- 拉丁裔超重儿童中IR及其相关生物标志物的患病率在很大程度上是未知的.
- 了解这些因素对于早期干预和管理至关重要.
研究的目的:
- 确定拉丁裔儿童青春期前和青春期过重 (超重和肥胖) 的IR患病率.
- 探索各种低级炎症生物标志物的实用性,以确定IR状态.
- 调查性别和体重类别之间生物标志物的潜在差异.
主要方法:
- 该研究包括68名超重儿童和20名健康的正常体重儿童,平均年龄约为11岁.
- 评估了人类学参数,胰岛素水平和多种炎症生物标志物,包括中性粒细胞/淋巴细胞比率,血小板/淋巴细胞比率,TNF-α,IL-6,MCP-1,sCD40L,hs-CRP和髓氧化酶.
- 胰岛素耐药性 (IR) 通过使用适应性模式评估指数 (HOMA-IR) 确定,并确定性别和青春期特定的切断点.
主要成果:
- 观察到IR的高患病率,其中62%的超重儿童受到影响.
- 在超重/肥胖儿童和正常体重的对照者之间,在炎症生物标志物水平 (例如IL-6,MCP-1,TNF-α,hs-CRP,sCD40L) 中发现了显著的差异,性别之间存在差异.
- 尽管一些生物标志物 (MCP-1,sCD40L,红细胞沉积率) 和IR之间存在正相关性,但调整为BMIz-score,性别和年龄的回归分析表明,没有一个是IR状态的强有力的预测因素.
结论:
- 胰岛素抵抗 (IR) 的患病率在超重的拉丁裔儿童中尤为高.
- 虽然某些炎症生物标志物与体重状况和IR有关,但它们未被证明是该队列中IR的可靠预测因素.
- 需要进行进一步的研究,以确定超重儿科患者群体中IR的有效生物标志物.
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