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Updated: Aug 17, 2026

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ANKS1B编码的AIDA-1通过控制寡细胞功能来调节社会行为

Chang Hoon Cho1,2, Ilana Vasilisa Deyneko1, Dylann Cordova-Martinez1

  • 1Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.

Nature communications
|December 21, 2023
PubMed
概括

ANKS1B神经发育综合征 (ANDS) 涉及脑细胞 (寡细胞) 缺陷,影响髓化和社会行为. 针对小寡细胞成熟的治疗可以改善ANDS患者的社会缺陷.

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Allosteric Proteins-ATCase01:19

Allosteric Proteins-ATCase

Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...