PANoptosis的机制和相关的小分子化合物用于对抗疾病
Lian Wang1, Yanghui Zhu1,2, Lu Zhang1
1Department of Dermatology & Venerology and Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
Cell death & disease
|December 21, 2023
概括
PANoptosis是一种编程细胞死亡途径,涉及热,亡和亡,是复杂的,在疾病中起着双重作用. 向PANoptosis为各种人类疾病提供了有前途的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 病理学 病理学 病理学
背景情况:
- 编程细胞死亡 (PCD) 途径,如热亡,细胞亡和死亡,对于宿主防御和恒常状态至关重要.
- 泛亡是一种新发现的炎症性PCD途径,由泛亡体复合体调节,涉及热亡体,亡体和死亡体之间的交叉声.
- PANoptosis在各种疾病中的病原和作用是复杂的和低估的.
研究的目的:
- 在各种病理条件和人类疾病中提供关于PANoptosome和PANoptosis的观点.
- 总结PANoptosis的进展和相关的治疗策略 (激动剂/抑制剂) 在疾病中.
- 突出PANoptosis的双重作用,作为疾病发病和治疗中的双刃剑.
主要方法:
- 文献综述和关于PANoptosis的当前研究的综合.
- 在微生物感染,癌症,ALI/ARDS,缺血-再输和有机衰竭中PANoptosis参与的分析.
- 讨论针对PANoptosome关联成员的治疗策略.
主要成果:
- 泛光与广泛的疾病有关,包括感染,癌症和急性肺损伤.
- 泛症可以具有有害的影响 (例如,在COVID-19,ALI/ARDS中) 或具有保护作用 (例如,对HSV1,Francisella novicida和某些癌症).
- 针对PANoptosis的化合物和内源分子呈现出有前途的治疗途径.
结论:
- PANoptosis是许多人类疾病的重要因素,表现出取决于背景的效应.
- 针对PANoptosis,特别是通过调节PANoptosome组件,提供了潜在的治疗策略.
- 进一步的研究是必要的,以充分阐明PANoptosis在人类病理中的作用,并开发有效的治疗方法.
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