使用全球厚度的左心室缩的预后效用和特征
Magnus Lundin1, Einar Heiberg2,3, David Nordlund2
1Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet, Stockholm, Sweden.
Scientific reports
|December 21, 2023
概括
心血管磁共振 (CMR) 可以评估左心室 (LV) 缩. 全球壁厚 (GT) 是一种新的,易于计算的测量方法,有助于表征 LV 缩并预测预后,特别是在早期疾病中.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 生物医学工程 生物医学工程
背景情况:
- 心血管磁共振 (CMR) 对于测量左心室 (LV) 质量至关重要.
- 现有的LV壁厚度测量在预后评估方面存在局限性.
- 左心室缩 (LVH) 是心血管风险的重要指标.
研究的目的:
- 评估CMR. 衍生出的不同LV壁厚度测量的预后值.
- 引入和验证一个新的测量方法,全球墙壁厚度 (GT).
- 为了确定最优的措施来表征LV缩和预测结果.
主要方法:
- 对2543名心脏病患者和100名接受CMR的健康志愿者的回顾性分析.
- 计算LV质量,LV质量指数 (LVMI) 和一个新的全球壁厚 (GT/GTI).
- 使用考克斯回归来分析死亡或心力衰竭住院的预后分析,随访时间中位数为5.4年.
主要成果:
- 在整体患者队列中,LVMI是不良结果的最强预测因素 (HR 1.16).
- 全球壁厚与身体表面积 (GTI) 相比,也显示出显著的预后值 (HR 1.14).
- 在正常 LV 质量的患者中,GT 是最具预测性的措施 (HR 1.62),识别了早期疾病阶段.
结论:
- LVMI对于增加的 LV 质量具有很高的预后.
- GT是一种有价值的,易于计算的措施,可以改善风险分层,特别是在正常LV质量的患者中.
- 结合使用GT和LVMI可以有效地根据LV形态学将患者分为不同的预后组.
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