具有Redox功能的电子查询和对层次和网络生物系统的反控制
Sally Wang1,2,3, Chen-Yu Chen1,2,3, John R Rzasa2
1Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Nature communications
|December 21, 2023
概括
研究人员设计了生物氧化还原网络,以电子控制蛋白质,细胞和细胞联盟. 这使得复杂的,无线连接的生物电子设备能够用于先进的生物系统管理.
科学领域:
- 生物电子学 生物电子学
- 合成生物学 合成生物学
- 生物技术是生物技术.
背景情况:
- 微电子设备可以通过氧化还原反应与生物系统接口.
- 在多个层面 (蛋白质,细胞,联盟) 控制生物功能仍然是一个挑战.
研究的目的:
- 为电子审讯和控制设计生物氧化还原网络.
- 开发无线连接的生物电子设备,用于实时生物系统管理.
主要方法:
- 电气生物制造用于设备上的生物组件组装.
- 电极驱动的氧化还原数据传输和合成生物学用于编程酶活性和细胞功能.
- 重新连接大肠杆菌的oxyRS regulon,以基于算法反控制基因表达和定数感应通信.
主要成果:
- 由电极生成的过氧化控制的过氧化酶在设备上被证明是组装的.
- 在大肠杆菌中实现了细胞功能和基因表达的电遗传控制.
- 开发了一种电子控制的"双语"细胞,能够切换定决数传感通信.
- 成功地连接了不同的反氧导向设备以无线方式进行基于用户的控制.
结论:
- 工程生物氧化还原网络使生物系统的复杂电子控制成为可能.
- 方法方便对生物电子设备的先进理解和开发.
- 未来的应用包括复杂的生物系统管理和新生物技术.
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