饮食炎症指数和骨质疏松症在慢性病患者群体中的关系
Xinxuan Meng1,2,3,4,5,6, Wenxin Sha1,2,3,4,5,6, Xiaowei Lou1,3,4,5,6
1Kidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, China.
Scientific reports
|December 21, 2023
概括
较高的饮食炎症指数 (DII) 分数与慢性病 (CKD) 患者,特别是女性的骨质疏松症风险增加和骨矿物质密度 (BMD) 降低相关. 抗炎饮食可能会提供保护.
科学领域:
- 营养科学 营养科学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 炎症显著影响骨质疏松症的发展.
- 通过饮食炎症指数 (DII) 评估的饮食模式可能会影响骨质疏松症风险.
- 慢性病 (CKD) 患者中DII和骨质疏松症之间的关联仍然不清楚.
研究的目的:
- 在慢性病 (CKD) 患者群体中调查饮食炎症指数 (DII) 和骨质疏松症之间的关系.
- 评估CKD患者的DII和骨矿物密度 (BMD) 之间的关联.
主要方法:
- 利用了美国国家健康和营养检查调查 (NHANES) 中526名CKD患者的数据.
- 将DII水平分为四个定量组,并采用多变量回归模型.
- 进行了受限制的立方线和子组分析,以检查关联和相互作用.
主要成果:
- 在CKD患者中,骨质疏松症的患病率为25.3%.
- 较高的DII四分位数 (Q4与Q3) 与骨质疏松症的几率增加有关 (OR总计为2.09,女性为2.80).
- 在CKD患者中,DII与腰椎BMD负相关 (P<0.05),在子组分析中没有发现显著的相互作用.
结论:
- 在CKD患者,尤其是女性中,DII升高与骨质疏松症和腰椎下部BMD的风险更高有关.
- 抗炎性饮食干预可以成为CKD相关骨质疏松症的潜在保护策略.
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