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治疗急性淋巴细胞白血病的儿童中牙异常的患病率,严重程度和描述
Cynthia Boutin1, Nelly Huynh2, Pierre Rompré3
1Pediatric dentist in private practice.
Pediatric dentistry
|December 22, 2023
概括
牙异常影响了超过一半的急性淋巴细胞白血病 (ALL) 的儿科患者,这些患者根据最近的协议接受治疗. 早期诊断年龄显著增加异常患病率和严重程度,影响牙发育.
科学领域:
- 儿科瘤学 儿科瘤学
- 牙科医学 牙科医学
- 临床研究 临床研究
背景情况:
- 急性淋巴细胞白血病 (ALL) 治疗可能会导致显著的长期副作用.
- 牙异常是儿童癌症幸存者的已知并发症.
- 最近的治疗方案旨在尽量减少这种不良影响.
研究的目的:
- 评估治疗ALL的儿童牙异常的频率和特征.
- 评估最近达纳-法伯癌症研究所 (DFCI) 协议对牙健康的影响.
- 为了确定与牙异常相关的风险因素在这个人群中.
主要方法:
- 51名患者进行了临床和放射性口腔检查.
- 患者在11岁之前被诊断患有ALL,并在2000年9月之后接受治疗.
- 分析了诊断时的年龄和治疗方案,以确定与牙异常的相关性.
主要成果:
- 牙异常存在于51%的受试者中,微牙是最常见的 (39.2%).
- 在9.8%的患者中发生了受影响的永久第二牙.
- 在5岁或更年轻时诊断显著与异常发病率和严重程度的增加有关 (P<0.001).
结论:
- 最近的DFCI协议似乎已经减少了牙科疾病的总体流行率.
- 观察到的异常仍然会影响儿科ALL幸存者的牙弧和牙封闭的发展.
- 需要进一步的研究来证实ALL治疗与永久性第二大损伤之间的联系.
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