相关实验视频

Updated: Jul 7, 2025

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Published on: June 11, 2020

孕产妇暴露于赛沃兰会增加青少年后代患的易感性,因为它会中断内部神经元的发育

Xinyue Liang¹, Ming Jiang¹, Hao Xu²

¹Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai, China.

|December 22, 2023

概括

孕产妇暴露于赛沃兰会破坏内部神经元的迁移,增加青少年后代的风险和类似焦虑的行为. 这些与CXCL12/CXCR4通路相关的效应是暂时的,在成年后没有观察到.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
麻醉学麻醉学

背景情况:

一般麻醉暴露影响神经元功能发展.
内神经元与麻醉诱导的发育神经毒性有关.
麻醉剂暴露对神经发育的机制和长期影响尚未完全理解.

研究的目的:

为了研究母亲暴露于赛沃兰对后代神经发育的影响.
阐明麻醉引起的发育神经毒性的潜在机制.
评估产前麻醉剂暴露对行为和神经功能的长期影响.

主要方法:

怀孕的小鼠暴露在sevoflurane;后代评估了发作易感性,焦虑和抑郁.
使用免疫光学和电生理学分析皮层内部神经元迁移和特性.
通过qPCR,in situ杂交和子宫内电穿孔研究CXCL12/CXCR4信号通路.

主要成果:

孕产妇暴露于塞沃兰会增加青少年后代的发病易感性和焦虑类行为.
塞沃兰破坏了皮质内部神经元的迁移,并改变了快速升的内部神经元膜潜力.
确定CXCL12/CXCR4通路的下调是关键机制.

结论:

孕产妇麻醉会通过CXCL12/CXCR4通路损害内部神经元的迁移,增加青少年的易感性.
这项研究提供了关于全身麻醉的发育神经毒性及其与的联系的见解.
观察到的效应是短暂的,在成年后消失.

关键词:

麻醉神经毒性麻醉神经毒性通过CXCL12/CXCR4通路进行.的易感性的易感性神经间的接触性迁移.

更多相关视频

Pentylenetetrazole-Induced Kindling Mouse Model

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

相关概念视频

Arteries of the Lower Limbs

Arteries of the Lower Limbs

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...