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促进区域的选择在 domestication期间的复杂特征中起着重要的作用

Zhong-Tao Yin¹, Xiao-Qin Li¹, Yun-Xiao Sun¹

¹National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, MARA, China Agricultural University, No. 2 Yuanmingyuan West Rd, Beijing, 100193, China.

|December 22, 2023

概括

的化涉及选定的基因促进体,特别是ELOVL3,影响基因表达和脂肪沉积等特征. 这项研究强调了非编码变体在经济特征改进中的作用.

科学领域:

进化生物学是进化的生物学.
基因组学就是基因组学.
动物繁殖动物繁殖

背景情况:

化研究在确定复杂特征的关键因素方面面临挑战.
监管要素中的非编码变体起着至关重要的作用,但它们在 domestication过程中的影响还未得到充分研究.

研究的目的:

为了研究在化过程中基因调控元素中累积变异的作用.
了解子经济特征改善的遗传基础.

主要方法:

基因组重新排序,RNA-Seq,Hi-C和ATAC-Seq在黑和佩金身上进行.
使用多组基因分析来识别选定的基因促进体及其与基因表达和染色质可访问性的关联.

主要成果:

304个基因促进体在佩金中被特别选择,其中许多位于活性染色体中,在相关组织中高度表达.
ELOVL3基因促进体表现出强烈的分化,其变体影响了基因表达和脂质沉积.
过度表达ELOVL3增加了脂质沉积和不和脂肪酸丰富.

结论:

基因促进物选择对于 domestication期间的基因表达和表型变化至关重要.
在ELOVL3促进剂的变体显著影响的脂肪和长链脂肪酸含量.

关键词:

累积的变体累积的变体化是一种化.一个的.基因表达基因表达基因表达活动主办人活动主办人

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