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Intranasal Administration of CNS Therapeutics to Awake Mice
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鼻内胰岛素给药对老年心脏外科手术患者手术后狂妄症的预防的影响:多中心,双盲,随机,受控试验的研究方案
Yosuke Nakadate1, Mariko Yamada2, Natsuyo Kusuyama3
1Department of Anesthesiology, University of Tsukuba Hospital, 2-1-1, Amakubo, Tsukuba, Ibaraki, 305-8576, Japan. nakadate.yosuke.ge@ms.hosp.tsukuba.ac.jp.
Trials
|December 22, 2023
概括
这项研究调查了老年心脏手术患者的鼻内胰岛素是否能预防术后狂妄症. 结果可能为这种高风险群体的痴呆症预防提供新的策略.
科学领域:
- 老年医学 老年医学
- 心脏病学 心脏病学
- 神经学 神经学
背景情况:
- 手术后痴呆症 (POD) 是正在接受重大手术,特别是心脏手术的老年患者的日益严重的并发症 (高达50%).
- 鼻内胰岛素 (INI) 在改善认知功能和大脑新陈代谢方面表现有前途,没有任何不良影响.
- 在心脏手术后,INI在预防POD中的有效性仍未确立.
研究的目的:
- 评估心脏手术期间服用80 IU鼻内胰岛素是否可以预防术后狂妄症.
- 探索在接受心肺旁路术的患者中预防POD的战略选择.
主要方法:
- 一个多中心的,双盲的,随机的,受控的试验,涉及110名老年患者 (≥65岁) 接受心脏手术,心肺旁路.
- 参与者将被随机分配,接受内胰岛素或内盐水.
- 主要结局是手术后7天内POD的发生率;次要结局包括妄想持续时间,认知功能测试,疼痛评分和ICU停留.
主要成果:
- 数据收集正在进行中;结果尚未提供.
结论:
- 这项研究旨在确定鼻内胰岛素在心脏手术后预防POD的有效性.
- 调查结果可以为临床实践提供信息,并为在这个脆弱人群中管理POD提供新的治疗策略.
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