长期腹儿童的病因学,危险因素和微生物群组成:一个前性病例控制队列研究
Andrea Lo Vecchio1, Paolo Quitadamo2, Marco Poeta1
1Department of Translational Medical Science-Section of Pediatrics, University of Naples Federico II, Naples, Italy.
Acta paediatrica (Oslo, Norway : 1992)
|December 22, 2023
概括
儿童长期腹通常是由严重的肠道感染引起的. 虽然它与特定的风险因素或微生物组变化无关,但通常在没有特殊治疗的情况下消失.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 传染性疾病 传染性疾病
- 微生物组研究 微生物组研究
背景情况:
- 长期腹 (ProD) 被定义为持续超过一周的急性发作的腹.
- 病因,风险因素和ProD的管理还没有得到很好的定义.
- 了解ProD对于儿童医疗保健至关重要.
研究的目的:
- 评估住院儿童长期腹的病因,危险因素和治疗方法.
- 调查肠道微生物群在PROD中的潜在作用.
- 为了比较ProD病例与急性腹 (AD) 控制.
主要方法:
- 预期招募30天至14岁的儿童,腹持续7-14天 (ProD) 和有急性腹 (AD) 的对照.
- 用于便样本分析的16S rRNA基因安普利康的高通量测序.
- 在ProD和AD组之间比较临床表现,病因和潜在的风险因素.
主要成果:
- 68名患有ProD的儿童和104名患有AD的儿童被录取.
- 在这两组中,肠道感染是主要原因 (ProD 92.9% vs. AD 97.8%) 的情况.
- ProD与更高的细菌感染流行率 (30.8%与8.9%) 和更严重的初始临床表现有关,但不是特定的年龄,宿主因素或微生物组变化.
结论:
- 儿童的长期腹通常是由于严重的肠道感染导致的,其过程比预期的更长.
- 对于ProD.没有独特的特定风险因素或微生物组变化被确定.
- 在大多数情况下,ProD在没有特定的管理或治疗的情况下消失.
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